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Born in Carroll, Virginia, USA on 1846 to Eli Spence and Martha Ellen Jackson. Isham married Mary Frances Mabry and had 10 children. He passed away on 21 Jan 1933 in Merrimack, Blacksburg, Virginia, USA.
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Surname meaning for "Spence"
English and Scottish: metonymic occupational name for a servant employed in the pantry of a great house or monastery, from Middle English spense ‘larder’, ‘storeroom’ (a reduced form of Old French despense, from a Late Latin derivative of dispendere, past participle dispensus, ‘to weigh out or dispense’).