My information on the Despot/Despotovich family is very limited. The only individuals that I know of are all from Prizren Serbia. Dushan Mladen Despotovich was my great grandfather. His siblings were Ljubica, Stevan, Despot, Stanko, and Krsta. Their parents were Mladen Despotovich and Juley Denian. That is all the information that I have at this time.
So I cannot say for sure if there is a connection. Sorry